While the term “proton pump inhibitors” may not ring a bell, chances are, you know someone using them. Doctors recommend and prescribe this line of drugs to everyone from babies to senior citizens for the treatment of acid-related disorders such as heartburn, reflux, stomach ulcers, and GERD. Some are available over the counter (Prilosec OTC, Prevacid 24HR, Zegerid OTC) and others require a prescription (Nexium, Dexilant, Vimovo). For many patients, the benefits outweigh the risks. Others have suffered grave consequences after taking these drugs without realizing their potential link to chronic kidney disease, as well as other side effects. Whether you know someone who was harmed by PPIs, are currently taking them yourself, or simply wondering what the headlines are all about, consider these five alarming truths about some of America’s best-selling drugs.